解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the ge...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8110299
更新日期:2017-10-30 00:00:00
abstract::Crested wheatgrass (Agropyron cristatum L.) breeding programs aim to develop later maturing cultivars for extending early spring grazing in Western Canada. Plant maturity is a complex genetic trait, and little is known about genes associated with late maturity in this species. An attempt was made using RNA-Seq to prof...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8110291
更新日期:2017-10-25 00:00:00
abstract::Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100269
更新日期:2017-10-13 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. An ALS drug, Riluzole, has been shown to induce two different anticancer effects on hepatocellular carcinoma (HCC). In light of this finding, we explore the relationship between ALS and cancer, especially for HCC, from the molecular biological v...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100243
更新日期:2017-09-27 00:00:00
abstract::Magnaportheoryzae is a devastating plant pathogen, which has a detrimental impact on rice production worldwide. Despite its agronomical importance, some newly-emerging pathotypes often overcome race-specific disease resistance rapidly. It is thus desirable to develop a novel strategy for the long-lasting resistance of...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100241
更新日期:2017-09-26 00:00:00
abstract::Scutellaria baicalensis Georgi (Lamiaceae) is the source of the well-known traditional Chinese medicine "HuangQin" (Radix Scutellariae). Natural sources of S. baicalensis are rapidly declining due to high market demand and overexploitation. Moreover, the commercial products of Radix Scutellariae have often been found ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8090227
更新日期:2017-09-13 00:00:00
abstract::There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of linc...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8080203
更新日期:2017-08-18 00:00:00
abstract::One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affe...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8080195
更新日期:2017-08-03 00:00:00
abstract::Adiponectin plays an important role in energy homeostasis and metabolism in mammalian adipose tissue. In this study, the relationship between adiponectin gene (ADIPOQ) haplotypes and variation in growth and carcass traits in New Zealand (NZ) Romney lambs was investigated using General Linear Models (GLMs). Eight haplo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8060160
更新日期:2017-06-12 00:00:00
abstract::We employed Illumina 450 K Infinium microarrays to profile DNA methylation (DNAm) in neuronal nuclei separated by fluorescence-activated sorting from the postmortem orbitofrontal cortex (OFC) of heroin users who died from heroin overdose (N = 37), suicide completers (N = 22) with no evidence of heroin use and from con...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8060152
更新日期:2017-05-30 00:00:00
abstract::Genetic isolated populations have features that may facilitate genetic analyses and can be leveraged to improve power of mapping genes to complex traits. Our aim was to test the extent to which a population with a former history of geographic isolation and religious endogamy, and currently with one of the highest fert...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8050133
更新日期:2017-05-04 00:00:00
abstract::In genome analysis, k-mer-based comparison methods have become standard tools. However, even though they are able to deliver reliable results, other algorithms seem to work better in some cases. To improve k-mer-based DNA sequence analysis and comparison, we successfully checked whether adding positional resolution is...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8040122
更新日期:2017-04-19 00:00:00
abstract::Winged bean (Psophocarpus tetragonolobus) is an herbaceous multipurpose legume grown in hot and humid countries as a pulse, vegetable (leaves and pods), or root tuber crop depending on local consumption preferences. In addition to its different nutrient-rich edible parts which could contribute to food and nutritional ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8030100
更新日期:2017-03-09 00:00:00
abstract::n/a. ...
journal_title:Genes
pub_type: 杂志文章,已发布勘误
doi:10.3390/genes8030091
更新日期:2017-03-03 00:00:00
abstract::MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8020082
更新日期:2017-02-20 00:00:00
abstract::RNA plays complex roles in normal health and disease and is becoming an important target for therapeutic intervention; accordingly, therapeutic strategies that modulate RNA function have gained great interest over the past decade. Antisense oligonucleotides (AOs) are perhaps the most promising strategy to modulate RNA...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8020051
更新日期:2017-01-26 00:00:00
abstract::Cancers can be categorized into two groups: those whose frequency increases with age, and those resulting from errors during mammalian development. The first group is linked to DNA replication through the accumulation of genetic mutations that occur during proliferation of developmentally acquired stem cells that give...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8020045
更新日期:2017-01-25 00:00:00
abstract::Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guideRNA design is already able to recruit another human deaminase, ADAR1,...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010034
更新日期:2017-01-14 00:00:00
abstract::Grouper is one of the favorite sea food resources in Southeast Asia. However, the outbreaks of the viral nervous necrosis (VNN) disease due to nervous necrosis virus (NNV) infection have caused mass mortality of grouper larvae. Many aqua-farms have suffered substantial financial loss due to the occurrence of VNN. To b...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010031
更新日期:2017-01-13 00:00:00
abstract::Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010027
更新日期:2017-01-11 00:00:00
abstract::Serotonin receptor 2A (HTR2A) is an important signalling factor implicated in cognitive functions and known to be associated with schizophrenia. The biological significance of HTR2A in schizophrenia remains unclear as molecular analyses including genetic association, mRNA expression and methylation studies have report...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010014
更新日期:2017-01-04 00:00:00
abstract::A large number of studies have focused on identifying molecular biomarkers, including microRNAs (miRNAs) to aid in the diagnosis and prognosis of the most common subtypes of non-Hodgkin lymphoma (NHL), Diffuse Large B-cell Lymphoma and Follicular Lymphoma. NHL is difficult to diagnose and treat with many cases becomin...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes7120130
更新日期:2016-12-17 00:00:00
abstract::Adverse environmental exposures in pregnancy can significantly alter the development of the fetus resulting in impaired child neurodevelopment. Such exposures can lead to epigenetic alterations like DNA methylation, which may be a marker of poor cognitive, motor and behavioral outcomes in the infant. Here we review st...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes7120117
更新日期:2016-12-03 00:00:00
abstract::The histone-like nucleoid structuring protein (H-NS) has played a key role in shaping the evolution of Shigella spp., and provides the backdrop to the regulatory cascade that controls virulence by silencing many genes found on the large virulence plasmid. H-NS and its paralogue StpA are present in all four Shigella sp...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes7120112
更新日期:2016-12-01 00:00:00
abstract::Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmo...
journal_title:Genes
pub_type:
doi:10.3390/genes7120108
更新日期:2016-11-29 00:00:00
abstract::While the clinical benefit of proteasome inhibitors (PIs) for multiple myeloma (MM) treatment remains unchallenged, dose-limiting toxicities and the inevitable emergence of drug resistance limit their long-term utility. Disease eradication is compromised by drug resistance that is either present de novo or therapy-ind...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7100084
更新日期:2016-10-06 00:00:00
abstract::The actin depolymerizing factor (ADF) proteins have growth, development, defense-related and growth regulatory functions in plants. The present study used genome-wide analysis to investigate ADF family genes in tomato. Eleven tomato ADF genes were identified and differential expression patterns were found in different...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7100079
更新日期:2016-09-29 00:00:00
abstract::Xeroderma pigmentosum group C (XPC) is a key component of the nucleotide excision repair (NER) pathway. Dysfunctional XPC protein may impair NER-mediated DNA repair capacity and further lead to genomic instability and carcinogenesis. Two common nonsynonymous polymorphisms in the XPC gene, Lys939Gln (rs2228001 A > C) a...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7100073
更新日期:2016-09-24 00:00:00
abstract::The homeodomain-leucine zipper (HD-Zip) transcription factor family is a key transcription factor family and unique to the plant kingdom. It consists of a homeodomain and a leucine zipper that serve in combination as a dimerization motif. The family can be classified into four subfamilies, and these subfamilies partic...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7050019
更新日期:2016-05-17 00:00:00
abstract::Bupleurum falcatum, which belongs to the family Apiaceae, has long been applied for curative treatments, especially as a liver tonic, in herbal medicine. The chloroplast (cp) genome has been an ideal model to perform the evolutionary and comparative studies because of its highly conserved features and simple structure...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7050020
更新日期:2016-05-13 00:00:00
abstract::Rapeseed contains glucosinolates, a toxic group of sulfur-containing glucosides, which play critical roles in defense against herbivores and microbes. However, the presence of glucosinolates in rapeseed reduces the value of the meal as feed for livestock. We performed association mapping of seed glucosinolate (GS) con...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes6041215
更新日期:2015-11-18 00:00:00
abstract::Epigenetics contributes to molecular mechanisms leading to tumor cell transformation and systemic progression of cancer. However, the dynamics of epigenetic remodeling during metastasis remains unexplored. In this context, circulating tumor cells (CTCs) might enable a direct insight into epigenetic mechanisms relevant...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6041053
更新日期:2015-10-21 00:00:00
abstract::Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6040957
更新日期:2015-09-30 00:00:00
abstract::The contribution of chromatin dynamics to the regulation of human disease-associated loci such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the focus of intensive experimentation for many years. Recent technological advances in the analysis of transcriptional mechanisms across the en...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6030543
更新日期:2015-07-13 00:00:00
abstract::It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and t...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6030484
更新日期:2015-07-07 00:00:00
abstract::Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes6030469
更新日期:2015-06-30 00:00:00
abstract::Several transcription factors (TFs) coordinate to regulate expression of specific genes at the transcriptional level. In Arabidopsis thaliana it is estimated that approximately 10% of all genes encode TFs or TF-like proteins. It is important to identify target genes that are directly regulated by TFs in order to under...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes5041115
更新日期:2014-12-19 00:00:00
abstract::Long non-coding (lnc) RNAs serve a multitude of functions in cells. NEAT1 RNA is a highly abundant 4 kb lncRNA in nuclei, and coincides with paraspeckles, nuclear domains that control sequestration of paraspeckle proteins. We examined NEAT1 RNA levels and its function in 3T3-L1 cells during differentiation to adipocyt...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes5041050
更新日期:2014-11-27 00:00:00
abstract::Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes5040926
更新日期:2014-09-29 00:00:00
abstract::MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that act as post-transcriptional gene regulators. They can inhibit target protein-coding genes, through repressing messenger RNA (mRNA) translation or promoting their degradation. miRNAs were initially found to be originated from nuclear genome an...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes5040865
更新日期:2014-09-26 00:00:00